Across TCGA patient cohorts, LEKR1 mutation is significantly associated with the RNA expression of many other genes, with 4,455 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEKR1-associated genes across cancer lineages are RNU4-45P, ACTR3BP2, and NOL12. Each is linked with LEKR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LEKR1-to-partner and partner-to-LEKR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEKR1→partner) and Y-score (partner→LEKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU4-45P →	+0.175	+4.757	<.001	.004	3	3
SKCM	ACTR3BP2 →	+0.006	+4.003	<.001	.006	3	3
SKCM	NOL12 →	+0.464	+3.623	<.001	.001	3	2
UCEC	CRYBB2P1 →	+0.439	+2.136	<.001	<.001	3	2
SKCM	DHODH →	+0.400	+3.951	.004	<.001	3	2
SKCM	POLR2C →	+0.493	+3.632	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,455 associations by consensus.

Exploration

LEKR1 survival (RNA) · tumor vs normal (RNA) · all LEKR1 data types