Across TCGA cell cohorts, LEKR1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LEKR1-associated genes across cancer lineages are DEFA4, C8A, and NPY5R. Each is linked with LEKR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEKR1-to-partner and partner-to-LEKR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEKR1→partner) and Y-score (partner→LEKR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFA4 →	+0.031	+4.662	<.001	.005	3	1
BLOOD_Lymphoma	C8A →	+0.043	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	NPY5R →	+0.018	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP5-3 →	+0.041	+4.523	<.001	.004	3	1
BLOOD_Leukemia	GFRA4 →	+0.483	+4.409	<.001	.005	3	1
BLOOD_Leukemia	GC →	+0.172	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

LEKR1 survival (RNA) · tumor vs normal (RNA) · all LEKR1 data types