LEFTY2

Across TCGA patient cohorts, LEFTY2 mutation is significantly associated with the RNA expression of many other genes, with 589 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEFTY2-associated genes across cancer lineages are RNU6-74P, CTLA4, and LCP2. Each is linked with LEFTY2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LEFTY2-to-partner and partner-to-LEFTY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-74P grouped by LEFTY2-low versus LEFTY2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY2→partner) and Y-score (partner→LEFTY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-74P →	+0.465	+4.428	.003	.002	3	3
UCEC	CTLA4 →	+1.243	+3.332	<.001	.005	3	2
UCEC	LCP2 →	+0.831	+3.470	.001	.003	3	2
UCEC	GTSE1 →	+0.815	+3.523	.005	.002	3	2
UCEC	PRORY →	+0.032	+4.148	<.001	.006	3	2
UCEC	IGHD3-22 →	+1.747	+2.466	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 589 associations by consensus.

RNU6-74P by LEFTY2 expression — COAD

Explore this box plot interactively →