LEFTY2

Across TCGA patient cohorts, LEFTY2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEFTY2-associated genes across cancer lineages are VHL, p62 Lck ligand, and Cyclin-B1. Each is linked with LEFTY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEFTY2-to-partner and partner-to-LEFTY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by LEFTY2-low versus LEFTY2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY2→partner) and Y-score (partner→LEFTY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.487	-3.000	<.001	.036	3	2
UCEC	p62 Lck ligand →	+0.427	+2.817	.023	.036	3	1
UCEC	Cyclin-B1 →	+0.889	+3.000	.006	.037	3	1
UCEC	Tuberin →	+0.515	+2.817	<.001	.036	2	1
UCEC	Caspase-8 →	-0.333	-3.000	.022	.037	1	1
UCEC	4E-BP1 →	+0.395	+3.000	.011	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

VHL by LEFTY2 expression — UCEC

Explore this box plot interactively →