LEFTY2

Across TCGA cell cohorts, LEFTY2 RNA expression is significantly associated with the go_rna of many other GO terms, with 481 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LEFTY2-associated GO terms across cancer lineages are Urokinase plasminogen activator signaling pathway, Regulation of potassium ion transport, and Negative regulation of amyloid-beta clearance. Each is linked with LEFTY2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LEFTY2-to-partner and partner-to-LEFTY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Urokinase plasminogen activator signaling pathway grouped by LEFTY2-low versus LEFTY2-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY2→partner) and Y-score (partner→LEFTY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Urokinase plasminogen activator signaling pathway →	-0.589	-0.689	<.001	.001	3	4
CNS	Regulation of potassium ion transport →	-0.090	-0.592	<.001	.002	3	4
CNS	Negative regulation of amyloid-beta clearance →	+0.096	+0.642	.001	.004	3	3
CNS	Regulation of potassium ion transmembrane transport →	-0.087	-0.435	.001	.005	3	3
CNS	Cellular response to reactive nitrogen species →	-0.095	-0.547	.002	.004	2	4
CNS	Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure →	-0.381	-0.450	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 481 associations by consensus.

Urokinase plasminogen activator signaling pathway by LEFTY2 expression — CNS

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