LEFTY2

Across TCGA cell cohorts, LEFTY2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LEFTY2-associated genes across cancer lineages are MSGN1, S100G, and TAFA1. Each is linked with LEFTY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEFTY2-to-partner and partner-to-LEFTY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by LEFTY2-low versus LEFTY2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY2→partner) and Y-score (partner→LEFTY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.069	+3.930	.002	.003	3	1
LARGE_INTESTINE	S100G →	+1.651	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.336	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	MINAR2 →	+0.044	+4.882	<.001	<.001	3	1
LARGE_INTESTINE	DAZ2 →	+0.204	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.008	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MSGN1 by LEFTY2 expression — LARGE_INTESTINE

Explore this box plot interactively →