LEFTY1

Across TCGA patient cohorts, LEFTY1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,117 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible LEFTY1-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of double-strand break repair, and Macromolecule deacylation. Each is linked with LEFTY1 in more than 17 cancer types. Because this analysis shows association rather than direction, both LEFTY1-to-partner and partner-to-LEFTY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by LEFTY1-low versus LEFTY1-high in KIRP.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY1→partner) and Y-score (partner→LEFTY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	Positive regulation of DNA repair →	+0.032	+1.248	<.001	<.001	2	18
KIRP	Positive regulation of double-strand break repair →	+0.038	+1.345	<.001	<.001	3	16
UVM	Macromolecule deacylation →	+0.057	+0.426	<.001	<.001	3	16
UVM	Regulation of DNA repair →	+0.034	+0.516	<.001	<.001	3	15
UVM	U2-type prespliceosome assembly →	+0.045	+0.306	<.001	<.001	3	15
UVM	Telomere maintenance in response to DNA damage →	+0.028	+0.328	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,117 associations by consensus.

Positive regulation of DNA repair by LEFTY1 expression — KIRP

Explore this box plot interactively →