LEFTY1

Across TCGA patient cohorts, LEFTY1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,503 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LEFTY1-associated genes across cancer lineages are ARMT1, MT1X, and C2CD4A. Each is linked with LEFTY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEFTY1-to-partner and partner-to-LEFTY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LEFTY1 versus ARMT1 in UCEC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY1→partner) and Y-score (partner→LEFTY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARMT1 →	-0.844	-1.344	.007	<.001	3	2
UCEC	MT1X →	-0.942	-1.051	.003	.005	3	2
UCEC	C2CD4A →	+1.657	+1.282	<.001	<.001	3	2
UCEC	SNRPGP3 →	-1.261	-1.158	<.001	.001	3	2
UCEC	GGT1 →	+0.447	+0.988	.004	.009	3	1
UCEC	CRYBB1 →	-1.034	-1.121	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,503 associations by consensus.

LEFTY1 vs ARMT1 — UCEC

Explore this scatter interactively →