LEFTY1

Across TCGA patient cohorts, LEFTY1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEFTY1-associated genes across cancer lineages are eIF4E, ERK2, and GAPDH. Each is linked with LEFTY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEFTY1-to-partner and partner-to-LEFTY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LEFTY1-low versus LEFTY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY1→partner) and Y-score (partner→LEFTY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.241	+2.700	.011	.006	3	1
UCEC	ERK2 →	+0.180	+2.999	.038	.035	3	1
UCEC	GAPDH →	+0.544	+3.169	.024	.018	3	1
UCEC	IGFBP2 →	-0.740	-2.000	.011	.032	3	1
UCEC	MEK1 →	+0.515	+3.584	.001	.002	3	1
UCEC	p62 Lck ligand →	+0.574	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by LEFTY1 expression — UCEC

Explore this box plot interactively →