LEFTY1

Across TCGA cell cohorts, LEFTY1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,197 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LEFTY1-associated GO terms across cancer lineages are Golgi vesicle transport, Vesicle-mediated transport to the plasma membrane, and Fertilization. Each is linked with LEFTY1 in more than 8 cancer types. Because this analysis shows association rather than direction, both LEFTY1-to-partner and partner-to-LEFTY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi vesicle transport grouped by LEFTY1-low versus LEFTY1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY1→partner) and Y-score (partner→LEFTY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Golgi vesicle transport →	+0.062	+0.389	<.001	.001	1	9
LUNG_SCLC	Vesicle-mediated transport to the plasma membrane →	+0.041	+0.367	.004	.003	2	7
SKIN	Fertilization →	-0.049	-0.075	.002	.008	3	6
LUNG_NSCLC_LUAD	Negative regulation of amyloid precursor protein catabolic process →	+0.070	+0.103	.005	.008	3	5
LUNG_NSCLC_LUSC	Positive regulation of viral process →	+0.090	+0.321	.002	.009	3	5
LIVER	Regulation of glucose mediated signaling pathway →	+0.118	+0.535	.006	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,197 associations by consensus.

Golgi vesicle transport by LEFTY1 expression — BREAST

Explore this box plot interactively →