LEFTY1

Across TCGA cell cohorts, LEFTY1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LEFTY1-associated genes across cancer lineages are FHL5, DCD, and OR2J2. Each is linked with LEFTY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEFTY1-to-partner and partner-to-LEFTY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FHL5 grouped by LEFTY1-low versus LEFTY1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEFTY1→partner) and Y-score (partner→LEFTY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FHL5 →	+0.216	+5.415	<.001	.004	3	1
SKIN	DCD →	+0.068	+4.977	.001	.007	3	1
SKIN	OR2J2 →	+0.013	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FHL5 by LEFTY1 expression — SKIN

Explore this box plot interactively →