LEF1

Across TCGA patient cohorts, LEF1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,049 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEF1-associated genes across cancer lineages are LEF1-AS1, AXIN2, and MFAP2. Each is linked with LEF1 in more than 7 cancer types. Because this analysis shows association rather than direction, both LEF1-to-partner and partner-to-LEF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LEF1 versus LEF1-AS1 in UCEC, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEF1→partner) and Y-score (partner→LEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LEF1-AS1 →	+1.164	+1.118	<.001	<.001	3	8
UCEC	AXIN2 →	+1.704	+1.216	<.001	<.001	3	5
GBM	MFAP2 →	+1.349	+0.780	.003	.003	3	4
UCEC	KLF12 →	+1.065	+0.937	<.001	<.001	3	4
UCEC	HMCN1 →	+1.380	+0.889	<.001	<.001	3	4
UCEC	KIF26B →	+1.366	+0.920	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,049 associations by consensus.

LEF1 vs LEF1-AS1 — UCEC

Explore this scatter interactively →