LEF1

Across TCGA patient cohorts, LEF1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEF1-associated genes across cancer lineages are EGFR_pY1068, GATA6, and ACVRL1. Each is linked with LEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEF1-to-partner and partner-to-LEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LEF1-low versus LEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEF1→partner) and Y-score (partner→LEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.259	-3.169	.022	.019	3	1
UCEC	GATA6 →	-0.182	-1.992	.009	.031	3	1
UCEC	ACVRL1 →	-0.125	-3.302	.042	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-1.986	.020	.032	3	1
UCEC	MEK1 →	+0.540	+2.700	.001	.006	3	1
UCEC	mTOR_pS2448 →	-0.142	-3.156	.034	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by LEF1 expression — UCEC

Explore this box plot interactively →