LEF1

Across TCGA cell cohorts, LEF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,274 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LEF1-associated GO terms across cancer lineages are Regulation of RNA stability, Calcium ion transport, and Regulation of microtubule-based process. Each is linked with LEF1 in more than 8 cancer types. Because this analysis shows association rather than direction, both LEF1-to-partner and partner-to-LEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA stability grouped by LEF1-low versus LEF1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEF1→partner) and Y-score (partner→LEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of RNA stability →	+0.064	+1.920	<.001	.002	3	9
LUNG_NSCLC_LUSC	Calcium ion transport →	-0.060	-2.730	.002	<.001	3	8
OESOPHAGUS	Regulation of microtubule-based process →	+0.060	+2.059	.006	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Recombinational repair →	+0.083	+1.765	<.001	<.001	3	8
BLOOD_Leukemia	Negative regulation of interleukin-13 production →	+1.537	+6.875	<.001	<.001	3	8
BONE	Negative regulation of interleukin-5 production →	+1.608	+4.004	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,274 associations by consensus.

Regulation of RNA stability by LEF1 expression — STOMACH

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