LEF1

Across TCGA cell cohorts, LEF1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LEF1-associated genes across cancer lineages are PFN3 and OR10W1. Each is linked with LEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEF1-to-partner and partner-to-LEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by LEF1-low versus LEF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEF1→partner) and Y-score (partner→LEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	2
LARGE_INTESTINE	OR10W1 →	+0.024	+5.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PFN3 by LEF1 expression — LARGE_INTESTINE

Explore this box plot interactively →