LECT2

Across TCGA patient cohorts, LECT2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LECT2-associated genes across cancer lineages are mTOR, S6_pS240_S244, and eEF2. Each is linked with LECT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LECT2-to-partner and partner-to-LECT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by LECT2-low versus LECT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LECT2→partner) and Y-score (partner→LECT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.149	-1.700	.030	.044	3	2
UCEC	S6_pS240_S244 →	+0.389	+2.906	.024	.001	3	2
UCEC	eEF2 →	+0.377	+3.169	.012	.018	3	1
UCEC	EGFR_pY1068 →	-0.270	-2.222	.011	.011	3	1
UCEC	FASN →	+0.356	+3.321	.033	.010	3	1
UCEC	GAPDH →	+0.576	+3.321	.011	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR by LECT2 expression — UCEC

Explore this box plot interactively →