LECT2

Across TCGA cell cohorts, LECT2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LECT2-associated genes across cancer lineages are KLRC4, C1QTNF8, and PABPN1L. Each is linked with LECT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LECT2-to-partner and partner-to-LECT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLRC4 grouped by LECT2-low versus LECT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LECT2→partner) and Y-score (partner→LECT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLRC4 →	+0.554	+3.748	<.001	.004	3	1
LARGE_INTESTINE	C1QTNF8 →	+0.218	+3.451	<.001	.008	3	1
LARGE_INTESTINE	PABPN1L →	+0.042	+3.376	<.001	.002	3	1
BLOOD_Leukemia	PRKAG3 →	+0.021	+4.551	.004	.004	3	1
BLOOD_Leukemia	ZP4 →	+0.012	+4.539	<.001	.007	3	1
BLOOD_Leukemia	WFDC12 →	+0.244	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KLRC4 by LECT2 expression — LARGE_INTESTINE

Explore this box plot interactively →