LEAP2

Across TCGA patient cohorts, LEAP2 protein abundance is significantly associated with the RNA expression of many other genes, with 925 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LEAP2-associated genes across cancer lineages are MFAP4, F10, and ITIH3. Each is linked with LEAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LEAP2-to-partner and partner-to-LEAP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LEAP2 versus MFAP4 in LSCC, with a Pearson correlation of 0.86.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEAP2→partner) and Y-score (partner→LEAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MFAP4 →	+1.713	+0.784	<.001	.005	3	3
LUAD	F10 →	+1.028	+0.743	<.001	<.001	3	2
LSCC	ITIH3 →	+0.919	+1.117	.003	.001	3	2
LSCC	GPD1 →	+1.147	+1.126	.008	.003	3	2
LSCC	DES →	+1.715	+0.813	.003	.003	3	2
LSCC	A2M →	+1.365	+0.770	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 925 associations by consensus.

LEAP2 vs MFAP4 — LSCC

Explore this scatter interactively →