LEAP2

Across TCGA patient cohorts, LEAP2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LEAP2-associated genes across cancer lineages are RNA5SP414, MIR378E, and MIR4698. Each is linked with LEAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LEAP2-to-partner and partner-to-LEAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by LEAP2-low versus LEAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LEAP2→partner) and Y-score (partner→LEAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.954	+3.670	<.001	.002	3	1
UCEC	MIR378E →	+0.374	+4.132	<.001	.009	3	1
UCEC	MIR4698 →	+0.427	+3.616	.001	.005	3	1
UCEC	MIR4672 →	+0.510	+3.041	.004	.008	3	1
UCEC	MIR4689 →	+0.371	+3.718	<.001	.004	3	1
UCEC	MIR4520-1 →	+1.217	+3.594	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

RNA5SP414 by LEAP2 expression — UCEC

Explore this box plot interactively →