LEAP2

Across TCGA cell cohorts, LEAP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,519 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LEAP2-associated GO terms across cancer lineages are DNA topological change, mRNA splice site recognition, and Pre-mRNA catabolic process. Each is linked with LEAP2 in more than 13 cancer types. Because this analysis shows association rather than direction, both LEAP2-to-partner and partner-to-LEAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA topological change grouped by LEAP2-low versus LEAP2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LEAP2→partner) and Y-score (partner→LEAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA topological change →	+0.143	+0.934	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.157	+0.879	<.001	<.001	3	14
BONE	Pre-mRNA catabolic process →	+0.211	+0.995	<.001	<.001	3	14
BONE	Subtelomeric heterochromatin formation →	+0.175	+1.053	<.001	<.001	3	14
BONE	Microtubule nucleation →	+0.114	+0.863	<.001	<.001	3	13
BONE	Late viral transcription →	+0.145	+0.959	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,519 associations by consensus.

DNA topological change by LEAP2 expression — SOFT_TISSUE

Explore this box plot interactively →