Across TCGA patient cohorts, LDOC1 mutation is significantly associated with the RNA expression of many other genes, with 2,019 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDOC1-associated genes across cancer lineages are IGHD5-12, DEFB129, and PANK4. Each is linked with LDOC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LDOC1-to-partner and partner-to-LDOC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDOC1→partner) and Y-score (partner→LDOC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHD5-12 →	+0.779	+3.145	<.001	.009	3	3
HNSC	DEFB129 →	+0.067	+5.468	<.001	.002	3	2
UCEC	PANK4 →	+0.341	+2.753	.002	.002	3	2
UCEC	PKN3 →	+0.697	+2.939	<.001	<.001	3	2
UCEC	GFI1 →	+0.423	+3.584	.002	.002	3	2
UCEC	MOB3A →	+0.339	+3.633	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,019 associations by consensus.

Exploration

LDOC1 survival (RNA) · tumor vs normal (RNA) · all LDOC1 data types