LDLRAD4

Across TCGA patient cohorts, LDLRAD4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLRAD4-associated genes across cancer lineages are FoxM1, MIG-6, and mTOR_pS2448. Each is linked with LDLRAD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAD4-to-partner and partner-to-LDLRAD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by LDLRAD4-low versus LDLRAD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD4→partner) and Y-score (partner→LDLRAD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.248	+1.807	.004	.004	3	2
UCEC	MIG-6 →	+0.079	+1.261	.019	.029	3	2
UCEC	mTOR_pS2448 →	-0.125	-1.787	.013	.026	3	2
UCEC	p62 Lck ligand →	+0.448	+3.000	<.001	<.001	3	2
UCEC	PCNA →	+0.262	+2.523	<.001	<.001	3	2
UCEC	PDCD4 →	-0.509	-2.459	.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FoxM1 by LDLRAD4 expression — UCEC

Explore this box plot interactively →