LDLRAD4-AS1

Across TCGA pan-cancer cohorts, LDLRAD4-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LDLRAD4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where LDLRAD4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types LDLRAD4-AS1 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, THCA, and KIRP are the cancer types where LDLRAD4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LDLRAD4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.483	<.001	8	view →
THCA	All	II,III,IV	−0.260	<.001	8	view →
KIRP	Male	All	−0.205	.003	8	view →
HNSC	Male	All	−0.073	<.001	8	view →
COAD	All	II,III,IV	−0.083	<.001	7	view →
UCEC	All	III,IV	−0.475	<.001	6	view →
LUAD	Female	II,III,IV	−0.459	<.001	6	view →
KIRC	All	II,III,IV	−0.216	.001	5	view →
BLCA	All	All	−0.137	.005	5	view →
READ	Male	All	−0.110	.002	5	view →
KICH	All	All	−0.620	<.001	4	view →
LIHC	All	II,III,IV	−0.134	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LDLRAD4-AS1–LUSC

Open the LUSC breakdown →