Across TCGA patient cohorts, LDLRAD2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDLRAD2-associated genes across cancer lineages are EGFR_pY1068, Gab2, and MEK1. Each is linked with LDLRAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDLRAD2-to-partner and partner-to-LDLRAD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDLRAD2→partner) and Y-score (partner→LDLRAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.351	-3.459	.005	.005	3	1
UCEC	Gab2 →	+0.418	+3.169	.019	.019	3	1
UCEC	MEK1 →	+0.388	+2.321	.034	.035	3	1
UCEC	Shc_pY317 →	-0.205	-3.459	.007	.005	3	1
UCEC	STAT3_pY705 →	-0.356	-2.321	.006	.035	3	1
UCEC	Cyclin-B1 →	+0.689	+2.321	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

LDLRAD2 survival (RNA) · tumor vs normal (RNA) · all LDLRAD2 data types