LDHD

Across TCGA pan-cancer cohorts, LDHD mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LDHD data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LDHD mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LDHD expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where LDHD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.825	.001	72	view →
LSCC	DFS	Median	II,III,IV	0.680	0.874	.009	20	view →
PDAC	DFS	Quartile	All	0.796	0.616	.016	14	view →
LUAD	DFS	Quartile	All	1.000	0.587	.013	6	view →
HNSC	OS	Tertile	III,IV	0.963	0.828	.038	2	view →
UCEC	DFS	Median	All	0.936	1.000	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LDHD–CCRCC (OS)

Open the CCRCC breakdown →