LDHD

Across TCGA patient cohorts, LDHD protein abundance is significantly associated with the RNA expression of many other genes, with 8,618 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LDHD-associated genes across cancer lineages are ST6GALNAC1, FBXO5, and KIF23. Each is linked with LDHD in more than 5 cancer types. Because this analysis shows association rather than direction, both LDHD-to-partner and partner-to-LDHD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LDHD versus ST6GALNAC1 in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHD→partner) and Y-score (partner→LDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ST6GALNAC1 →	+1.270	+0.423	<.001	<.001	3	6
GBM	FBXO5 →	-0.803	-0.366	<.001	.001	3	6
OV	KIF23 →	-0.976	-0.567	.006	.002	3	6
BRCA	NRM →	-0.593	-0.499	<.001	<.001	3	5
BRCA	PRIM2 →	-0.723	-0.721	<.001	<.001	3	5
LSCC	KNTC1 →	-0.697	-0.414	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,618 associations by consensus.

LDHD vs ST6GALNAC1 — LSCC

Explore this scatter interactively →