LDHD

Across TCGA patient cohorts, LDHD mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHD-associated genes across cancer lineages are ERK2, JNK2, and MEK1. Each is linked with LDHD in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHD-to-partner and partner-to-LDHD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by LDHD-low versus LDHD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHD→partner) and Y-score (partner→LDHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.173	+2.000	.019	.030	3	1
UCEC	JNK2 →	+0.307	+2.348	<.001	.018	3	1
UCEC	MEK1 →	+0.414	+2.584	.003	.001	3	1
UCEC	p62 Lck ligand →	+0.298	+3.710	.017	<.001	3	1
UCEC	PDCD4 →	-0.501	-2.105	.005	.017	3	1
UCEC	AMPK_pT172 →	+0.362	+1.335	.021	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ERK2 by LDHD expression — UCEC

Explore this box plot interactively →