LDHB

Across TCGA pan-cancer cohorts, LDHB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LDHB data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LDHB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LDHB expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where LDHB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.501	0.254	.003	20	view →
HNSC	DFS	Median	II,III,IV	0.879	0.994	.001	17	view →
LUAD	OS	Quartile	All	0.442	0.808	.009	8	view →
LSCC	DFS	Tertile	All	0.883	0.453	.030	7	view →
CCRCC	OS	Tertile	II,III,IV	0.603	0.894	.037	7	view →
UCEC	DFS	Median	All	0.852	0.949	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LDHB–PDAC (DFS)

Open the PDAC breakdown →