LDHB

Across TCGA cell cohorts, LDHB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,823 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LDHB-associated GO terms across cancer lineages are 'de novo' IMP biosynthetic process, Ribosomal small subunit biogenesis, and rRNA processing. Each is linked with LDHB in more than 13 cancer types. Because this analysis shows association rather than direction, both LDHB-to-partner and partner-to-LDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 'de novo' IMP biosynthetic process grouped by LDHB-low versus LDHB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHB→partner) and Y-score (partner→LDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	'de novo' IMP biosynthetic process →	+0.157	+0.967	.004	.007	3	14
BONE	Ribosomal small subunit biogenesis →	+0.162	+1.115	<.001	<.001	3	14
BONE	rRNA processing →	+0.154	+1.203	<.001	<.001	3	12
BONE	Ribosome biogenesis →	+0.147	+0.971	<.001	.003	3	12
BLOOD_Lymphoma	Ribosome assembly →	+0.094	+0.763	<.001	<.001	3	12
BONE	rRNA metabolic process →	+0.133	+0.804	<.001	.002	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,823 associations by consensus.

'de novo' IMP biosynthetic process by LDHB expression — BONE

Explore this box plot interactively →