LDHAL6A

Across TCGA patient cohorts, LDHAL6A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDHAL6A-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and MEK1. Each is linked with LDHAL6A in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHAL6A-to-partner and partner-to-LDHAL6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by LDHAL6A-low versus LDHAL6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHAL6A→partner) and Y-score (partner→LDHAL6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.195	-3.169	.016	.019	3	1
UCEC	JNK2 →	+0.249	+2.459	.009	.020	3	1
UCEC	MEK1 →	+0.448	+3.169	.011	.018	3	1
UCEC	Myosin-IIa →	+0.261	+3.332	.003	.005	3	1
UCEC	Notch1 →	+0.221	+2.820	.001	.035	3	1
UCEC	p21 →	+0.248	+3.183	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by LDHAL6A expression — UCEC

Explore this box plot interactively →