LDHAL6A

Across TCGA cell cohorts, LDHAL6A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDHAL6A-associated genes across cancer lineages are GUCY2F, PPP1R17, and GSG1L2. Each is linked with LDHAL6A in more than 1 cancer types. Because this analysis shows association rather than direction, both LDHAL6A-to-partner and partner-to-LDHAL6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUCY2F grouped by LDHAL6A-low versus LDHAL6A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDHAL6A→partner) and Y-score (partner→LDHAL6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GUCY2F →	+0.010	+4.273	.001	.006	3	1
LARGE_INTESTINE	PPP1R17 →	+0.055	+4.467	.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
SKIN	OR52N4 →	+0.202	+4.977	<.001	.007	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GUCY2F by LDHAL6A expression — LARGE_INTESTINE

Explore this box plot interactively →