LDB2

Across TCGA patient cohorts, LDB2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDB2-associated genes across cancer lineages are Rad50, Cyclin-B1, and A-Raf_pS299. Each is linked with LDB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LDB2-to-partner and partner-to-LDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by LDB2-low versus LDB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB2→partner) and Y-score (partner→LDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.281	-2.058	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.615	+4.000	<.001	<.001	3	3
SKCM	A-Raf_pS299 →	+0.110	+1.887	.049	.029	3	3
UCEC	14-3-3_beta →	-0.076	-1.973	.017	.008	3	2
UCEC	FoxM1 →	+0.226	+1.777	.006	.002	3	2
UCEC	IRS1 →	-0.174	-3.807	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Rad50 by LDB2 expression — UCEC

Explore this box plot interactively →