LDB2

Across TCGA cell cohorts, LDB2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDB2-associated genes across cancer lineages are ITGAD, OR1N2, and RTP2. Each is linked with LDB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDB2-to-partner and partner-to-LDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAD grouped by LDB2-low versus LDB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB2→partner) and Y-score (partner→LDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ITGAD →	+0.009	+4.510	.009	.001	3	1
LARGE_INTESTINE	OR1N2 →	+0.095	+3.930	<.001	.003	3	1
LARGE_INTESTINE	RTP2 →	+0.015	+4.217	<.001	.001	3	1
LARGE_INTESTINE	MOG →	+0.137	+4.054	<.001	.004	3	1
LARGE_INTESTINE	ARRDC5 →	+0.060	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ITGAD by LDB2 expression — LARGE_INTESTINE

Explore this box plot interactively →