Across TCGA pan-cancer cohorts, LDB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LDB1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LDB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LDB1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, COAD, and LUAD are the cancer types where LDB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.729	0.993	.009	24	view →
COAD	DFS	Median	III,IV	0.853	1.000	.039	6	view →
LUAD	OS	Tertile	III,IV	0.733	0.219	.023	4	view →
LSCC	DFS	Tertile	III,IV	0.903	0.515	.033	2	view →
CCRCC	DFS	Quartile	II,III,IV	0.809	0.419	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: LDB1 tumor-vs-normal RNA expression · all LDB1 data types