Across TCGA patient cohorts, LDB1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDB1-associated genes across cancer lineages are JNK_pT183_Y185, EGFR_pY1068, and eIF4E. Each is linked with LDB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDB1-to-partner and partner-to-LDB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB1→partner) and Y-score (partner→LDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.219	-3.459	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.283	-2.807	.009	.003	3	1
UCEC	eIF4E →	+0.203	+3.906	.027	<.001	3	1
UCEC	JNK2 →	+0.250	+2.115	.004	.019	3	1
UCEC	Ku80 →	+0.265	+2.128	.010	.010	3	1
UCEC	MEK1 →	+0.482	+3.906	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

LDB1 survival (RNA) · tumor vs normal (RNA) · all LDB1 data types