Across TCGA cell cohorts, LDB1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LDB1-associated genes across cancer lineages are HTR1B, CPLX4, and OR4F5. Each is linked with LDB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LDB1-to-partner and partner-to-LDB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDB1→partner) and Y-score (partner→LDB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HTR1B →	+0.068	+4.029	<.001	.004	3	1
LARGE_INTESTINE	CPLX4 →	+0.044	+4.392	<.001	.004	3	1
LARGE_INTESTINE	OR4F5 →	+0.029	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

LDB1 survival (RNA) · tumor vs normal (RNA) · all LDB1 data types