LDAH

Across TCGA pan-cancer cohorts, LDAH mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LDAH’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LDAH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LDAH is over-expressed in tumor, although a few such as PDAC and OV show the opposite, repressed pattern.

LUAD, LSCC, and PDAC are the cancer types where LDAH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LDAH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.342	<.001	9	view →
LSCC	Male	III,IV	+0.429	<.001	8	view →
PDAC	Male	All	−0.547	<.001	7	view →
COAD	All	All	+0.107	.002	7	view →
HNSC	All	All	+0.213	<.001	6	view →
OV	All	All	−0.313	.049	2	view →
CCRCC	All	All	−0.112	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

LDAH–LUAD

Open the LUAD breakdown →