LDAH

Across TCGA patient cohorts, LDAH mutation is significantly associated with the RNA expression of many other genes, with 3,886 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDAH-associated genes across cancer lineages are MIR3661, TPRX1P1, and MIR6803. Each is linked with LDAH in more than 1 cancer types. Because this analysis shows association rather than direction, both LDAH-to-partner and partner-to-LDAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by LDAH-low versus LDAH-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDAH→partner) and Y-score (partner→LDAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3661 →	+0.380	+4.208	<.001	.003	3	2
LUSC	TPRX1P1 →	+0.424	+5.978	<.001	.002	3	2
SKCM	MIR6803 →	+0.409	+4.743	<.001	.005	3	2
UCEC	PTP4A1P7 →	+0.127	+1.863	.004	.003	3	2
UCEC	TCP11X3P →	+0.229	+1.895	<.001	.002	3	2
CESC	RNU1-62P →	+0.182	+4.539	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,886 associations by consensus.

MIR3661 by LDAH expression — SKCM

Explore this box plot interactively →