LDAH

Across TCGA patient cohorts, LDAH mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LDAH-associated genes across cancer lineages are A-Raf_pS299, FASN, and FoxM1. Each is linked with LDAH in more than 1 cancer types. Because this analysis shows association rather than direction, both LDAH-to-partner and partner-to-LDAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by LDAH-low versus LDAH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LDAH→partner) and Y-score (partner→LDAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.189	-2.459	<.001	.019	3	1
UCEC	FASN →	+0.343	+1.906	.030	.016	3	1
UCEC	FoxM1 →	+0.326	+3.087	.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.136	-2.690	.006	.006	3	1
UCEC	GATA6 →	-0.129	-2.000	.043	.030	3	1
UCEC	INPP4B →	-0.481	-3.074	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

A-Raf_pS299 by LDAH expression — UCEC

Explore this box plot interactively →