LDAH

Across TCGA cell cohorts, LDAH RNA expression is significantly associated with the go_rna of many other GO terms, with 3,040 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LDAH-associated GO terms across cancer lineages are DNA-templated DNA replication, tRNA methylation, and 7-methylguanosine mRNA capping. Each is linked with LDAH in more than 7 cancer types. Because this analysis shows association rather than direction, both LDAH-to-partner and partner-to-LDAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by LDAH-low versus LDAH-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LDAH→partner) and Y-score (partner→LDAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DNA-templated DNA replication →	+0.087	+0.743	<.001	.004	3	8
BLOOD_Lymphoma	tRNA methylation →	+0.065	+0.937	<.001	<.001	3	8
SOFT_TISSUE	7-methylguanosine mRNA capping →	+0.088	+0.804	.002	.006	3	7
SOFT_TISSUE	Positive regulation of ERK1 and ERK2 cascade →	-0.063	-0.809	.003	.002	3	7
BONE	tRNA processing →	+0.060	+0.741	<.001	<.001	3	7
SOFT_TISSUE	7-methylguanosine RNA capping →	+0.088	+0.804	.002	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,040 associations by consensus.

DNA-templated DNA replication by LDAH expression — BLOOD_Lymphoma

Explore this box plot interactively →