Across TCGA patient cohorts, LCTL RNA expression is significantly associated with the protein abundance of many other proteins, with 12,751 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LCTL-associated proteins across cancer lineages are PLOD1, P3H1, and CRTAP. Each is linked with LCTL in more than 7 cancer types. Because this analysis shows association rather than direction, both LCTL-to-partner and partner-to-LCTL results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LCTL→partner) and Y-score (partner→LCTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLOD1 →	+0.705	+0.985	<.001	<.001	3	8
GBM	P3H1 →	+0.741	+0.934	<.001	<.001	3	7
GBM	CRTAP →	+0.700	+1.011	<.001	<.001	3	6
OV	IKBIP →	+0.539	+0.430	<.001	<.001	3	5
GBM	COLGALT1 →	+0.537	+0.842	.001	<.001	2	6
OV	SERPINH1 →	+0.574	+0.436	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,751 associations by consensus.

Exploration

LCTL survival (RNA) · tumor vs normal (RNA) · all LCTL data types