Across TCGA cell cohorts, LCTL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,040 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LCTL-associated GO terms across cancer lineages are Regulation of chromosome organization, Regulation of metaphase/anaphase transition of cell cycle, and Spindle organization. Each is linked with LCTL in more than 12 cancer types. Because this analysis shows association rather than direction, both LCTL-to-partner and partner-to-LCTL results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LCTL→partner) and Y-score (partner→LCTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome organization →	+0.097	+0.319	.001	.008	3	13
OESOPHAGUS	Regulation of metaphase/anaphase transition of cell cycle →	+0.155	+0.245	.001	.003	3	12
OESOPHAGUS	Spindle organization →	+0.100	+0.289	.003	<.001	3	12
BLOOD_Myeloma	Sister chromatid segregation →	+0.108	+0.200	<.001	<.001	3	12
OESOPHAGUS	Mitotic cell cycle checkpoint signaling →	+0.110	+0.401	<.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.094	+0.315	<.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,040 associations by consensus.

Exploration

LCTL survival (RNA) · tumor vs normal (RNA) · all LCTL data types