Across TCGA cell cohorts, LCTL mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCTL-associated genes across cancer lineages are OR2B2, SLC35G4, and OR6J1. Each is linked with LCTL in more than 1 cancer types. Because this analysis shows association rather than direction, both LCTL-to-partner and partner-to-LCTL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCTL→partner) and Y-score (partner→LCTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2B2 →	+0.029	+4.669	.001	<.001	3	2
LUNG_NSCLC_LUAD	SLC35G4 →	+0.018	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR6J1 →	+0.042	+4.285	<.001	.006	3	1
LUNG_NSCLC_LUAD	CT45A7 →	+0.049	+3.947	<.001	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

LCTL survival (RNA) · tumor vs normal (RNA) · all LCTL data types