Across TCGA pan-cancer cohorts, LCT-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LCT-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher LCT-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LCT-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, ACC, and KIRP are the cancer types where LCT-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.412	0.268	<.001	111	view →
ACC	OS	Tertile	All	0.491	0.847	<.001	93	view →
KIRP	DFS	Quartile	All	0.745	0.889	<.001	75	view →
HNSC	DFS	Quartile	All	0.786	0.622	<.001	73	view →
MESO	OS	Median	II,III,IV	0.275	0.508	<.001	50	view →
CHOL	DFS	Tertile	II,III,IV	0.834	0.131	.005	40	view →
KIRC	OS	Median	All	0.575	0.727	.002	34	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
ESCA	DFS	Median	III,IV	0.457	0.242	.013	12	view →
THYM	OS	Median	II,III,IV	0.928	0.683	.010	12	view →
LUAD	DFS	Quartile	III,IV	0.660	0.294	.021	11	view →
UVM	DFS	Tertile	All	0.534	0.777	.047	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: LCT-AS1 tumor-vs-normal RNA expression · all LCT-AS1 data types