LCP1

Across TCGA patient cohorts, LCP1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCP1-associated genes across cancer lineages are STAT3_pY705, ATM, and 14-3-3_beta. Each is linked with LCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCP1-to-partner and partner-to-LCP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by LCP1-low versus LCP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCP1→partner) and Y-score (partner→LCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.339	-2.311	<.001	.005	3	2
UCEC	ATM →	-0.342	-2.308	.040	.033	3	2
UCEC	14-3-3_beta →	-0.082	-1.847	.026	.049	3	1
UCEC	JNK2 →	+0.254	+1.710	<.001	.025	3	1
UCEC	MEK1 →	+0.480	+3.087	<.001	<.001	3	1
UCEC	Notch1 →	+0.108	+1.502	.037	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

STAT3_pY705 by LCP1 expression — UCEC

Explore this box plot interactively →