LCP1

Across TCGA cell cohorts, LCP1 mutation is significantly associated with the RNA expression of many other genes, with 653 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCP1-associated genes across cancer lineages are PLA2G3, ANKRD54, and DEPDC5. Each is linked with LCP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LCP1-to-partner and partner-to-LCP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by LCP1-low versus LCP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCP1→partner) and Y-score (partner→LCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G3 →	+1.089	+3.540	<.001	.002	3	1
LARGE_INTESTINE	ANKRD54 →	+0.561	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	DEPDC5 →	+0.594	+3.321	.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.600	+3.160	.001	.006	3	1
LARGE_INTESTINE	MCAT →	+0.788	+3.502	<.001	.001	3	1
LARGE_INTESTINE	FZD3 →	+0.903	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 653 associations by consensus.

PLA2G3 by LCP1 expression — LARGE_INTESTINE

Explore this box plot interactively →