LCP1

Across TCGA cell cohorts, LCP1 mutation is significantly associated with the mutation status of many other genes, with 4,630 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LCP1-associated genes across cancer lineages are DCAF5, EIF3H, and PAXIP1. Each is linked with LCP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LCP1-to-partner and partner-to-LCP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCAF5 grouped by LCP1-low versus LCP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCP1→partner) and Y-score (partner→LCP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCAF5 →	+2.767	+2.409	.001	.001	1	3
LARGE_INTESTINE	EIF3H →	+3.182	+2.584	<.001	<.001	1	3
LARGE_INTESTINE	PAXIP1 →	+1.959	+1.959	.009	.009	1	3
LARGE_INTESTINE	BMP10 →	+4.767	+2.992	<.001	<.001	1	3
LARGE_INTESTINE	PAQR3 →	+4.182	+2.574	.003	.003	1	3
LARGE_INTESTINE	LMOD1 →	+4.504	+2.781	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,630 associations by consensus.

DCAF5 by LCP1 expression — LARGE_INTESTINE

Explore this box plot interactively →