Across TCGA pan-cancer cohorts, LCOR mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LCOR data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LCOR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LCOR expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where LCOR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.897	0.656	.003	26	view →
HNSC	OS	Median	IV	0.580	0.824	.006	12	view →
PDAC	OS	Tertile	II,III,IV	0.665	0.371	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: LCOR tumor-vs-normal RNA expression · all LCOR data types