Across TCGA patient cohorts, LCOR mutation is significantly associated with the RNA expression of many other genes, with 1,545 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCOR-associated genes across cancer lineages are MIR548AW, RNU6-728P, and MIR4480. Each is linked with LCOR in more than 1 cancer types. Because this analysis shows association rather than direction, both LCOR-to-partner and partner-to-LCOR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCOR→partner) and Y-score (partner→LCOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR548AW →	+0.377	+5.252	<.001	.002	3	2
BLCA	RNU6-728P →	+0.536	+5.106	<.001	.008	3	2
SKCM	MIR4480 →	+0.307	+4.469	<.001	.006	3	2
SKCM	FAM32DP →	+0.065	+6.816	<.001	<.001	3	2
HNSC	RNU7-81P →	+0.427	+5.069	.002	.008	3	2
SKCM	RNU1-19P →	+0.181	+4.097	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,545 associations by consensus.

Exploration

LCOR survival (RNA) · tumor vs normal (RNA) · all LCOR data types