Across TCGA patient cohorts, LCOR mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LCOR-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Rab25. Each is linked with LCOR in more than 1 cancer types. Because this analysis shows association rather than direction, both LCOR-to-partner and partner-to-LCOR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LCOR→partner) and Y-score (partner→LCOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.230	-2.906	<.001	.001	3	2
UCEC	MEK1 →	+0.298	+2.087	.033	.005	3	2
UCEC	Rab25 →	-0.312	-3.321	.014	.009	3	2
UCEC	Annexin-1 →	+0.667	+1.926	<.001	.008	3	2
UCEC	ASNS →	+0.533	+2.222	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.306	-2.584	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

LCOR survival (RNA) · tumor vs normal (RNA) · all LCOR data types